The Weber Lab is part of the Department of Aquatic Ecology at the Swiss Federal Institute of Aquatic Science and Technology (Eawag). Our research focuses on the evolutionary genomics of invasive quagga mussels and on the conservation genomics of native European mussel species. We combine fieldwork, laboratory experiments, and high-throughput ‘omics’ data to investigate the molecular mechanisms of plasticity and adaptation across ecological and evolutionary timescales. Using transcriptomic, epigenomic, and genomic approaches, we study the processes underlying invasion success, sex determination, and rapid environmental responses in invasive mussels. In parallel, we examine the resilience, population structure, and vulnerability of native European mussel populations facing environmental change. Our research integrates population genetics, ecology, and bioinformatics to support evidence-based strategies for biodiversity conservation and freshwater ecosystem management.